Spontaneous hyperplasia❗ Ewelina lives at risk❗.

Unexpected diagnosis

In August 2025, an ordinary, routine blood test changed the course of seventeen-year-old Evelina's daily life. The results, which were supposed to be a mere formality, revealed an alarmingly high platelet count. At first, doctors suspected a temporary disorder, but subsequent analyses left no illusions. A detailed hematological diagnosis was initiated, including a bone marrow biopsy and trepanobiopsy. On October 21, 2025, a final diagnosis was made - spontaneous hyperplasia with mutation of the CALR gene.

The disease you can't see

Spontaneous hyperplasia is a bone marrow disease in which the body produces an excessive number of platelets. Their excess disrupts the natural balance and increases the risk of blood clots, strokes, heart attacks or hemorrhages. For Ewelina, this means she has to constantly live under doctors' supervision, with regular checkups and pharmacotherapy aimed at keeping platelets within a safe range.

This condition is chronic and requires constant vigilance. Over the years, it can develop into other hematopoietic malignancies like myelofibrosis, which leads to bone marrow scarring, or turn into acute myeloid leukemia (AML). Over time, Ewelina's list of health problems began to expand.
The primary diagnosis included secondary von Willebrand syndrome, which disrupts the clotting process and increases the tendency to bleed, as well as dysthymia and recurrent depressive disorders, affecting her mood and daily functioning.

Treatment

After the diagnosis, therapy was implemented, which initially offered hope for stabilization. However, during a subsequent check-up at Cape Hope, the platelet count rose again, exceeding 1,600,000/µl, which led to an emergency hospitalization. Subsequent results confirmed that despite treatment, their levels remained very high - over 1,300,000, so doctors decided to change therapy and introduce hydroxyurea, which is designed to inhibit platelet proliferation. This is accompanied by frequent headaches, malaise and the need for regular hematology checks, including weekly blood counts and monthly visits to Cape Hope. In case of sudden deterioration of parameters, immediate hospitalization is necessary.

Everyday life under control

Ewelina remains under constant hematological care. Each week brings new results, checks and hospital visits. The disease, though invisible, forces constant vigilance and discipline. From a seventeen-year-old girl, it requires maturity, patience and perseverance, which help tame a daily life dominated by treatment. On a daily basis , Ewelina lives with her mother and brother Jacob, who is on the autism spectrum. Her mom raises the children alone, trying to provide them with security, stability and treatment options. Ewelina's illness has put additional strain on the family, for whom every day is an ordeal of balancing daily responsibilities with care, therapy and hospital visits.

Purpose of the collection

The funds raised in this collection will be used to purchase medications, commute to regular hematology check-ups, diagnostic tests, and support in daily functioning related to chronic treatment. Any help will allow Ewelina to maintain continuity of treatment and a sense of security.